Ma ke ʻano he hōʻike no ka "ʻano hānau ʻole" o ka makemake i ka moekolohe, hoʻohana pinepine nā mea hoʻoikaika LGBT* i kahi noiʻi i ka makahiki 1991 na ka neurobiologist ʻo Simon LeVay, kahi āna i ʻike ai ua like ka nui o ka hypothalamus o nā kāne "homosexual" me ko nā wahine, ka mea i manaʻo ʻia he homosexual lākou. He aha ka mea a LeVay i ʻike ai? ʻO ka mea āna i ʻike ʻole ai, ʻo ia ka pilina ma waena o ke ʻano o ka lolo a me nā makemake moekolohe.